5-Bromo-2-methyl-4-pyrimidinecarboxylic acid

5-Bromo-2-methyl-4-pyrimidinecarboxylic acid - Names and Identifiers

Name	5-Bromo-2-methyl-4-pyrimidinecarboxylic acid
Synonyms	2-Methyl-5-bromopyrimidine-4-carboxylicaci 5-Bromo-2-methylpyrimidin-4-carboxylic acid 5-Bromo-2-methylpyrimidine-4-carboxylic acid 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid 2-methyl-5-bromopyrimidine-4-carboxylic acid 4-Pyrimidinecarboxylic acid, 5-bromo-2-methyl- 4-PyriMidinecarboxylic acid, 5-broMo-2-Methyl-
CAS	100707-39-9
InChI	InChI=1/C6H5BrN2O2/c1-3-8-2-4(7)5(9-3)6(10)11/h2H,1H3,(H,10,11)

5-Bromo-2-methyl-4-pyrimidinecarboxylic acid - Physico-chemical Properties

Molecular Formula	C6H5BrN2O2
Molar Mass	217.02
Density	1.795±0.06 g/cm3(Predicted)
Melting Point	172-173 °C (decomp)(Solv: methanol (67-56-1))
Boling Point	335.2±27.0 °C(Predicted)
Flash Point	156.505°C
Vapor Presure	0mmHg at 25°C
pKa	1.53±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.61

5-Bromo-2-methyl-4-pyrimidinecarboxylic acid - Reference Information

Uses

2-methyl-5-bromopyrimidin-4-carboxylic acid is a useful research chemical for organic synthesis and other chemical processes. Pyrimidine compounds are widely found in the human body and organisms. The development of such compounds has been paid attention to by the pharmaceutical and pesticide circles.

Preparation

Using 2,4-dimethyl-5-bromopyrimidine as the starting material, under alkaline conditions, potassium permanganate is oxidized to prepare the target compound 2-methyl-5-bromopyrimidin-4-carboxylic acid [1]. Or using 3, 4-dibromo-5-hydroxyfuran-2 (5h)-one as the starting material, and forming a pyrimidine ring with acetamidine hydrochloride to prepare 2-methyl-5-bromopyrimidine-4-carboxylic acid. The synthesis reaction formula of 2-methyl-5-bromopyrimidin-4-carboxylic acid is as follows: Figure 1 Synthesis reaction formula of 2-methyl-5-bromopyrimidin-4-carboxylic acid

Last Update：2024-04-09 02:00:05